Versioned claims
Definitions and scientific claims are identified, dated, and changed through explicit revisions rather than silent rewriting.
Scientific infrastructure · open development
Research Programme
The Programme turns a developing theoretical framework into a transparent scientific system: explicit definitions, atomic pathways, testable claims, reproducible operationalizations, and evidence that can be independently scrutinized, replicated, and cumulatively studied.
Purpose
Make the framework easier to test than to merely agree with.
The Programme’s task is not to preserve the Pathogenetic Triad from criticism. It is to make its components, causal proposals, boundaries, and empirical implications precise enough that competing explanations can be compared.
Autism is the initial and most developed module. Transdiagnostic expansion is necessary for assessing the specificity of the framework and should follow only where phenotype-specific constructs and predictions can be defined with comparable rigor.
Testability before utility
Construct validity, independent replication, and critical testing must precede claims of diagnostic, prognostic, or treatment utility.
One canon, several renditions
Research, clinical, and plain-language explanations share one scientific record and cannot diverge in status or meaning.
Independent challenge
The Programme is designed so researchers outside the founding group can test, qualify, or refute its predictions.
Staged public release
Publish the stable foundation first; add the full testing system next.
This website begins as a credible public front door and authoritative terminology reference. The broader canonical release will add structured postulate, prediction, test, study, and evidence registries after their relationships and review process are ready for public use.
Now
Stage one · public foundation
Framework, pathways, vocabulary, Q&A, history, publications, programme, and leadership
Establishes the programme’s identity, current scientific status, canonical definitions, formal pathway families, explanatory layer, model and publication history, and contact point.
Next
Stage two · canonical research release
Postulates, predictions, tests, studies, and evidence
Adds searchable linked records, versioned scholarly snapshots and summaries of findings across samples, operationalizations, and models, contribution routes, planned and ongoing studies, and listings of independent research using or critically testing the framework.
Programme workstreams
One knowledge system, developed through five connected lines of work.
The workstreams are coordinated parts of the same source of record and should produce reusable scientific objects rather than duplicate prose.
Scientific canon
Maintain the specification, definitions, pathway families, nomenclature, boundaries, explanations, and revision history.
Measurement
Develop construct-faithful measurement models for trait profiles, Cognitive Capacity, and Neurodevelopmental Burden.
Critical tests
Convert claims into prespecified predictions and reusable test specifications, then evaluate them in independent data.
Evidence stewardship
Link results to the exact prediction and operationalization they bear on, with direction, confidence, and limitations visible.
Open dissemination
Publish searchable records, frozen scholarly releases, accessible explanations, and listings of research using the PT.
Current invitation
Critical testing is part of the programme – not an external threat to it.
Researchers, clinicians, methodologists, and community members interested in construct development, measurement, replication, or adversarial testing are invited to make contact. Formal contribution and project-listing routes will be added in the broader release.
Contact the Programme