Model History

Included in v1.0

• The three core components are phenotype-specific trait profile, Cognitive Capacity, and Neurodevelopmental Burden.
• Functional and Clinical Expression is the integrative outcome of the framework.
• Clinical Diagnosis is a distinct downstream categorical classification.
• Five intrinsic causal and developmental pathway families and one Clinical Ascertainment Pathway are specified.
• Phenotype-formation, burden-formation, and burden–capacity pathways contain atomic relations that can be studied independently.
• Potential risk factors or exposures are separated from realized neurodevelopmental insults.
• The permeative environmental layer is distinguished from environmental inputs into burden formation and from ascertainment context.
• Canonical definitions, scope boundaries, Q&A records, and publication lineage are included in the public foundation.

Scientific status and boundaries

• Phenotype specificity is located primarily in the phenotype-specific trait profile.
• Cognitive Capacity and Neurodevelopmental Burden are broadly transdiagnostic.
• Environmental context is a cross-cutting moderator rather than a fourth triad component.
• No direct Neurodevelopmental Burden → expression or Neurodevelopmental Burden → trait-profile path is asserted in the canonical figure.
• The current empirical evidence is preliminary and operationalization-specific.
• The framework is not validated for individual diagnosis, prognosis, or treatment selection.